HIV Protease
HIV protease, a homodimeric aspartyl protease, is crucial for the viral life-cycle, cleaving proviral polyproteins, hence creating mature protein components that are required for the formation of an infectious virus. HIV protease cleaves newly synthesized polyproteins at the appropriate places to create the mature protein components of an infectious HIV virion. HIV protease is a critical drug target in designing anti-retroviral drugs to treat HIV/AIDS (acquired immune deficiency syndrome).
HIV-1 protease permits viral maturation by processing the Gag and Gag-Pro-Pol polyproteins. It recognizes and cleaves more than 12 different substrates leading to viral maturation. Similar to that of HIV-1, HIV-2 protease is also a homodimeric aspartyl enzyme that plays a vital role in the HIV life-cycle through processing of Gag and Gag-Pro-Pol precursor polyproteins leading to viral maturation.
All Product Categories
-
HIV Protease Related Products (203)
Related Products (203)
-
Ritonavir-13C3
0 ImagesCat. No.: HY-W653853CAS No.: 1217673-23-8Synonyms: ABT 538-13C3; RTV-13C3
-
Lopinavir-d8
0 ImagesCat. No.: HY-14588S1CAS No.: 1224729-35-4Lopinavir-d8 (ABT-378-d8) is the deuterium labeled Lopinavir. Lopinavir (ABT-378) is a highly potent, selective peptidomimetic inhibitor of the HIV-1 protease, with Kis of 1.3 to 3.6 pM for wild-type and mutant HIV protease. Lopinavir acts by arresting maturation of HIV-1 thereby blocking its infectivity. Lopinavir is also a SARS-CoV 3CLpro inhibitor with an IC50 of 14.2 μM.
-
GRL-142
0 ImagesCat. No.: HY-181888GRL-142 is a potent HIV-1 protease inhibitor capable of crossing the blood-brain barrier. GRL-142 exhibits extremely high inhibitory activity against both wild-type and multidrug-resistant strains (IC50=0.0094 nM). GRL-142 acts synergistically with the P2/P2' segments via a unique scaffold binding mechanism, utilizes fluorine-mediated stable interactions to maintain its bioactive conformation, adapts to p51 HIV-1 protease mutants, and maintains the flap-closed state by directly acting on the flap tip residues. GRL-142 disrupts the flap-water hydrogen bond network of wild-type protease, thereby effectively blocking viral replication. GRL-142 can be used to study HIV-1 infection and the associated neurocognitive disorder (HAND).
-
TMC310911 (Standard)
0 ImagesCat. No.: HY-107123RCAS No.: 1000287-05-7Synonyms: ASC-09 (Standard)TMC310911 (Standard) (ASC-09 (Standard)) is the analytical standard of TMC310911 (HY-107123). This product is intended for research and analytical applications. TMC310911 is a potent and orally active HIV type-1 (HIV-1) protease inhibitor with EC50 values ranged from 2.2 nM to 14.2 nM for wild-type HIV-1. TMC310911 has potent activity against a wide spectrum of recombinant HIV-1 isolates. TMC310911 has strong antiviral activity.
-
MDL-104168
0 ImagesCat. No.: HY-187058CAS No.: 158268-42-9
-
A-80987
0 ImagesCat. No.: HY-19194CAS No.: 144141-97-9
-
Rpi-856 A
0 ImagesCat. No.: HY-P1981CAS No.: 157381-54-9Rpi-856 A is a competitive inhibitor of HIV-1 protease and HTLV-I protease, with an IC50 of 37 nM against HIV-1 protease and an IC50 of 27 nM against HTLV-I protease. Rpi-856 A inhibits Pepsin with an IC50 of 1.9 μM. Rpi-856 A does not inhibit chymosin, trypsin, chymotrypsin, papain, bromelain, thermolysin, prolyl endopeptidase, carboxypeptidase A or carboxypeptidase B. Rpi-856 A can be used in the research of acquired immunodeficiency syndrome (AIDS) and related diseases, as well as HIV infection.
-
Escin IA (Standard)
0 ImagesCat. No.: HY-N0554RCAS No.: 123748-68-5Escin IA (Standard) is the analytical standard of Escin IA. This product is intended for research and analytical applications. Escin IA is a triterpene saponin isolated from Aesculus hippocastanum, which inhibits HIV-1 protease with IC50 values of 35 μM. Escin IA has anti-TNBC metastasis activity, and its action mechanisms involved inhibition of epithelial-mesenchymal transition process by down-regulating LOXL2 expression.
-
BMS 186318
0 ImagesCat. No.: HY-120616CAS No.: 161302-40-5BMS 186318 is an HIV protease inhibitor. BMS 186318 exhibits better anti-HIV efficacy when used in combination with reverse transcriptase inhibitors such as Stavudine (HY-B0116) and other protease inhibitors such as Saquinavir (HY-17007). BMS 186318 can be used in antiviral research.
-
ddCTP tetrasodium
0 ImagesCat. No.: HY-137697AddCTP tetrasodium is a type of chain-terminating deoxynucleotide. ddCTP tetrasodium can be incorporated into the extension primer chain that lacks the 3'-hydroxyl group, thereby terminating primer extension, viral genome replication, and DNA synthesis. ddCTP tetrasodium can distinguish almost identical RNA through distinguishable extension products in primer extension inhibition experiments. ddCTP tetrasodium is the active metabolite of Zalcitabine (HY-17392), which can competitively inhibit HIV reverse transcriptase, terminate the synthesis of viral DNA chains, and thereby inhibit HIV replication.
-
U 81749
0 ImagesCat. No.: HY-183376CAS No.: 126103-94-4U 81749 is a competitive, reversible HIV-1 protease inhibitor with a Ki value of 70 nM. U 81749 inhibits HIV-1 protease within HIV-like particles, blocks the processing of the HIV-1 gag polyprotein p55 into the mature structural proteins p24 and p17, and thereby prevents viral maturation. U 81749 reduces HIV p24 and HIV RNA levels in acutely infected human lymphocytes, and shows no toxicity to lymphocyte proliferation at effective concentrations. U 81749 can be used in studies related to HIV-1 infection.
-
Darunavir (Standard)
0 ImagesSynonyms: TMC114 (Standard); UIC-94017 (Standard)Darunavir (Standard) is the analytical standard of Darunavir. This product is intended for research and analytical applications. Darunavir (TMC114), an orally active next generation HIV protease inhibitor, has a similar antiviral activity against the mutant and the wild-type viruses. Darunavir (TMC114) is potent against laboratory HIV-1 strains and primary clinical isolates (IC50 = 0.003 μM; IC90 = 0.009 μM) with minimal cytotoxicity.
-
Opaviraline
0 ImagesCat. No.: HY-107003CAS No.: 178040-94-3Synonyms: GW420867XOpaviraline (GW420867X) is an anti-HIV-1 reverse transcriptase inhibitor.
-
Rpi-856 C
0 ImagesCat. No.: HY-P1982CAS No.: 157381-55-0Rpi-856 C is an Aspartic protease inhibitor, with an IC50 of 5.5 nM against HIV-1 protease, 9.2 nM against HTLV-I protease, 2.0 μM against Cathepsin D, and 4.8 μM against Pepsin. Rpi-856 C is produced by the Streptomyces strain AL-322. Rpi-856 C does not inhibit chymosin, trypsin, chymotrypsin, papain, bromelain, thermolysin, prolyl endopeptidase, carboxypeptidase A or carboxypeptidase B. Rpi-856 C can be used in the research of acquired immunodeficiency syndrome (AIDS) and related diseases, as well as HIV infection.
-
Fosamprenavir-13C6
0 ImagesCat. No.: HY-78726S2Synonyms: Amprenavir phosphate-13C6; GW 433908-13C6Fosamprenavir-13C6 is the 13C-labeled Fosamprenavir (HY-78726). Fosamprenavir is an orally active inhibitor targeting HIV-1 protease and is a prodrug of Amprenavir (HY-17430). Fosamprenavir is hydrolyzed into Amprenavir (VX-478) by cell phosphatases in the intestinal epithelium. Amprenavir binds to the active site of HIV-1 protease, preventing the processing of viral gag and gag-pol polyprotein precursors, thereby inhibiting the formation of mature infectious virus particles and exerting anti-HIV-1 infection activity. Fosamprenavir can be used for the study of human immunodeficiency virus (HIV-1) infection.
-
Ganoderic acid B (Standard)
0 ImagesCat. No.: HY-N2006RCAS No.: 81907-61-1Ganoderic acid B (Standard) is the analytical standard of Ganoderic acid B. This product is intended for research and analytical applications. Ganoderic acid B is a triterpene isolated from a mushroom Ganoderma lucidum. Ganoderic acid B inhibits the activation of Epstein-Barr virus (EBV) antigens as telomerase inhibitor. Ganoderic acid B is a moderately active inhibitor against HIV-1 protease (IC50: 170 μM).
-
Isoescin IA (Standard)
0 ImagesCat. No.: HY-N0556RCAS No.: 219944-39-5Isoescin IA (Standard) is the analytical standard of Isoescin IA. This product is intended for research and analytical applications. Isoescin IA is a triterpenoid saponin isolated from the seeds of Aesculus chinensis. Isoescin IA has anti-HIV-1 protease activity.
-
Ro 31-8588
0 ImagesCat. No.: HY-120712CAS No.: 141979-04-6
-
Hydroxy darunavir
0 ImagesCat. No.: HY-W702986CAS No.: 1130635-75-4
